A worldwide indication of the amount of water used in the manufacturing cycle of commodities is called the “Water Footprint.” The entire amount of freshwater used or contaminated throughout a commodity’s manufacturing is known as its “water footprint.” Water consumption mostly refers to the amount of water that plants need during the growth season (green and blue water), whereas water pollution (gray water) is primarily caused by fertilizer seeping from the field. To investigate the effects of varying irrigation and nitrogen dosage levels on vegetative growth characteristics, yield parameters, and chemical contents, an experiment was conducted on garlic plants during the two winter seasons of 2020–2021 and 2021–2022, at the Central Laboratory for Agricultural Climate (CLAC) research site, Dokki, Giza, Egypt. To investigate the effects of varying irrigation levels and nitrogen doses on vegetative growth characteristics, yield parameters, and chemical contents of garlic. The nitrous oxide (N2O) and water footprint (WFP) emissions were estimated using the collected data. Two elements make up the treatments: three main plots with irrigation levels of 80, 100, and 120% of the required water, and three subplots with nitrogen levels of 60, 80, and 100 kg doses, each three duplicated in a split-plot design. The findings demonstrated that under irrigation, the highest vegetative growth parameters, yield parameters, and chemical composition of leaves were observed. The results demonstrated that, at an irrigation level of 120% of the water requirements and 100 kg of nitrogen dose for the garlic plant, the highest vegetative growth characteristics, yield parameters, and chemical contents of leaves were recorded. The relationship between nitrogen doses and irrigation levels reveals that, when combined, 120% irrigation levels and 100 kg of nitrogen dose produced high yield parameters, vegetative growth characteristics, and chemical content in the leaves; this was followed by 100% irrigation levels and 100 kg of nitrogen dose with notable differences between the two. In all measurements, the combination of 80% irrigation levels and a 60kg nitrogen injection yielded the lowest value. Under 120% irrigation and 60 kg of nitrogen fertilizer, the water footprint for the output of fresh and cured garlic was higher, measuring 628 m3/ton and 959 m3/ton, respectively. The maximum emission of N2O with 100 kg of nitrogen and an irrigation level of 80%, the highest N2O emission value for cured garlic yield, was reported at 0.283 kg N2O per ton of cured garlic output, or 84.5 kg CO2/ton. With 100 kg of nitrogen and an irrigation level of 80%, the greatest N2O emission value for fresh garlic output was reported at 0.190 kg N2O per ton, or 56.7 kg CO2/ton.